# Curology DayPrimeRx Important Safety Information

> Tell your dermatology provider about any medical conditions and all medications you are taking before using this medication      This medication has an expirat

Source: https://support.curology.com/en_us/curology-dayprimerx-important-safety-information-SJF0vE6lx

Last updated: 2025-10-16T23:46:25.786Z

Tell your dermatology provider about any medical conditions and all medications you are taking before using this medication. 

This medication has an expiration or beyond use date. Do not use this medication after the date listed on the bottle. 

If you are currently pregnant or breastfeeding do not use your formula if it contains any of the following ingredients: clindamycin.

Please inform your medical provider of all allergies, including allergies to ingredients that may be in the DayPrimeRx. These may include:

*   Azelaic Acid
*   Clindamycin
*   Dexpanthenol
*   Niacinamide
*   Salicylic acid
*   Zinc pyrithione

DayPrimeRx is not recommended for use in patients younger than 13 years of age. 

Skin irritation may occur as a side effect of this medication. This can include burning, stinging, inflammation, skin peeling, dryness, redness, itching, and increased sensitivity to the sun. Please contact your medical provider if this occurs. 

To reduce the risk of skin irritation, you may want to avoid other products that may irritate the skin. This includes the use of abrasive soaps, exfoliants, and related chemicals or obtaining facial treatments, including but not limited to waxing and electrolysis. 

Further suggestions that may help minimize dryness/irritation include waiting at least 10-20 minutes after washing your face before applying your formula and applying the medication to start every other day and slowly increasing frequency as tolerated.

If you’re allergic to non-steroidal anti-inflammatory drugs (NSAIDs), like aspirin and ibuprofen, avoid using salicylic acid.

If your DayPrimeRx contains salicylic acid, you should discuss the use of your personalized formula with your in-person medical provider if you’re using other salicylates or drugs that can increase salicylate serum concentration, including aspirin, or if you have a history of kidney disease or liver disease. In general, salicylic acid should be avoided by those younger than 18 years old who have viral illnesses.

When used on its own, the antibiotic clindamycin can lead to bacterial resistance. To minimize this risk, it is recommended that clindamycin be used with other antimicrobial ingredients such as benzoyl peroxide. Our DayPrimeRx formulas containing clindamycin also contain zinc and/or azelaic acid which may also help.

Do not use if you are allergic to this medication or any of its ingredients.

Stop use and contact your healthcare provider right away if you develop symptoms of an allergic reaction such as rash, hives, itching, shortness of breath, wheezing, cough, or swelling of your face, lips, tongue, or throat.

Please tell your provider if: 

*   You are pregnant, breastfeeding, or trying to get pregnant.
*   You are using any products with retinoids (Vitamin A derivatives). Examples may include Adapalene, Epiduo®, Retinol, Tazorac® etc.
*   You have had any allergic reactions to skin care products.
*   If you have been diagnosed with Rosacea.
*   If you have a history of eczema, perioral dermatitis, skin cancer, or other skin conditions.

This treatment was designed to be applied once daily in the morning. Do not use more than your medical provider has instructed you to use. Do not swallow and avoid sensitive areas such as eyes, lips, and inside your mouth/nose. Do not use on cuts, scrapes, damaged (broken/chapped/cut/irritated/scraped) skin, recently shaved areas of the skin, or sunburned skin. Doing any of these things may increase the chance of undesirable side effects.

Please always follow your medical provider's specific directions on how to use your DayPrimeRx.